Li (Amily) Guo, M.D. Ph.D.

The Guo lab studies the immune functions of platelets and how they talk to white blood cells in healthy and disease conditions. Platelets are a type of small blood cells produced by megakaryocytes at ~100 billion cells/day in adults, essential for blood clotting upon injury. Abnormal platelet number or functions are a major cause of many diseases including cardiovascular diseases, bleeding disorders, cancer metastasis, impaired bacteria/virus killing during infection. Platelet transfusions are a commonly used therapy but with many limitations such as inflammatory side effects. The lab utilizes a wide range of techniques to better understand the platelet biogenesis and biology in health and diseases, which includes animal models, genetic, epigenetic and bioengineering tools, flow cytometry, intravital and confocal microscopy. We aim to develop the next generation platelet-centered products with specialized immune functions.

Areas of Study

  • The regulation of adaptive immunity by platelets
  • Ex vivo generation of future platelet products with specialized immune functions
  • Platelet actin cytoskeleton dynamics in platelet biogenesis and function

Dr. Guo’s Background

  • Joined Bloodworks Northwest in 2023
  • 2022-2023: Instructor, Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, School of Medicine, University of Utah,
  • 2016-2022: Postdoctoral Fellow, Molecular Medicine Program, University of Utah

Representative Publications

Click here to view.

Guo Laboratory Members

Kathryn Gilham
Research Technologist I
Email: [email protected]
Phone: 206-568-2258

Li (Amily) Guo, M.D. Ph.D.

Assistant Member
Director of Flow Cytometry Core
Bloodworks Northwest Research Institute

Bloodworks Northwest
Research Institute
1551 Eastlake Avenue E, Suite 100
Seattle, WA 98104

Email: [email protected]
Phone: (206) 568-2163
FAX: (206) 587-6056

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